Induction of vitellogenin and gonadal impairment in chub (Leuciscus cephalus L.) after exposure to 17beta-estradiol and testosterone
Jazyk angličtina Země Švédsko Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
20027175
PII: NEL300709A38
Knihovny.cz E-zdroje
- MeSH
- Cyprinidae krev fyziologie MeSH
- endokrinní disruptory toxicita MeSH
- estradiol toxicita MeSH
- oocyty účinky léků fyziologie MeSH
- ovarium účinky léků fyziologie MeSH
- pohlavní dimorfismus MeSH
- testis účinky léků fyziologie MeSH
- testosteron toxicita MeSH
- vitelogeniny krev metabolismus MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- endokrinní disruptory MeSH
- estradiol MeSH
- testosteron MeSH
- vitelogeniny MeSH
OBJECTIVES: A controlled laboratory study was carried out to quantify vitellogenin (VTG) concentrations in a common cyprinid freshwater fish, the chub (Leuciscus cephalus L.), exposed to steroid hormones. DESIGN: The effect of 17betaestradiol, testosterone and testosterone-estradiol mixture was investigated on vitellogenin induction. Gonad status was also determined. RESULTS: Oral exposure to estradiol and a testosterone-estradiol mixture increased (p < 0.01) blood plasma concentrations of VTG in blood plasma of both sexes. The testosterone-estradiol mixture had a negative effect on the investigated chub gonads. The effects were signified by histological changes when compared to control fish. CONCLUSION: Our results showed a significant VTG increase in blood plasma of both sexes, indicating that vitellogenic response in the chub is sensitive to steroid hormones.
