Nucleotide variability of Tahyna virus (Bunyaviridae, Orthobunyavirus) small (S) and medium (M) genomic segments in field strains differing in biological properties
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
20093153
DOI
10.1016/j.virusres.2010.01.005
PII: S0168-1702(10)00015-8
Knihovny.cz E-resources
- MeSH
- 3' Untranslated Regions MeSH
- 5' Untranslated Regions MeSH
- Phylogeny MeSH
- Genetic Variation * MeSH
- Genome, Viral MeSH
- Encephalitis, California virology MeSH
- Conserved Sequence MeSH
- Humans MeSH
- Molecular Sequence Data MeSH
- Mice MeSH
- Viral Plaque Assay MeSH
- Viral Envelope Proteins genetics MeSH
- RNA, Viral genetics MeSH
- Sequence Analysis, DNA MeSH
- Sequence Homology MeSH
- Cluster Analysis MeSH
- Virulence MeSH
- Encephalitis Virus, California genetics isolation & purification pathogenicity MeSH
- Hot Temperature MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- 3' Untranslated Regions MeSH
- 5' Untranslated Regions MeSH
- Viral Envelope Proteins MeSH
- RNA, Viral MeSH
Tahyna virus (TAHV), a mosquito-borne bunyavirus (California group), is frequently associated with inapparent or influenza-like (Valtice fever) infections in humans, rarely leading to atypical pneumonia or meningitis. Field TAHV strains exhibit a high variability in their biological properties with respect to virulence for laboratory mouse, temperature-sensitivity or character of plaques in cell culture. In consideration of the variations in the antigenic properties TAHV and its potential genetic variability, we analyzed complete nucleotide sequences of the small (S) and medium (M) genomic segments of field TAHV strains with different combinations of phenotypic markers. S segment was highly conservative in all analyzed TAHV strains. Within the M segment, the highest variability was observed in the G(C) gene encoding viral envelope protein and to a less extent also in the NSm gene. However, 5' and 3' non-coding regions of M segment, as well as in G(N) gene exhibited highly conservative pattern, indicating its functional importance, but minor or no role in the determination of biological properties of TAHV field strains.
References provided by Crossref.org
GENBANK
GQ386823, GQ386824, GQ386825, GQ386826, GQ386827, GQ386828, GQ386829, GQ386830, GQ386831, GQ386832, GQ386833, GQ386834, GQ386835, GQ386836, GQ386837, GQ386838, GQ386839, GQ386840, GQ386841, GU390669, GU390670, GU390671, GU390672, GU390673, GU390674, GU390675, GU390676, GU390677, GU390678, GU390679, GU390680, GU390681, GU390682, GU390683, GU390684, GU390685, GU390686, GU390687, GU390688
