Reactivation potency of the acetylcholinesterase reactivator obidoxime is limited
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
20208964
DOI
10.5507/bp.2009.044
Knihovny.cz E-resources
- MeSH
- Acetylcholinesterase metabolism MeSH
- Antidotes pharmacology MeSH
- Chemical Warfare Agents poisoning MeSH
- Rats MeSH
- Brain metabolism MeSH
- Obidoxime Chloride pharmacology MeSH
- Pesticides poisoning MeSH
- Cholinesterase Reactivators pharmacology MeSH
- In Vitro Techniques MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Acetylcholinesterase MeSH
- Antidotes MeSH
- Chemical Warfare Agents MeSH
- Obidoxime Chloride MeSH
- Pesticides MeSH
- Cholinesterase Reactivators MeSH
BACKGROUND: Obidoxime is the only one reactivator of acetylcholinesterase (AChE) approved in Czech Republic for the treatment of nerve agent and pesticide poisonings for civilian sector. Due to the fact that misuse of nerve agents by terrorists or by an accidental poisoning by farmers is possible, re-evaluation of its universality is needed. It is also needed by the fact that clinical findings considering this oxime are controversial. AIM: In this study, we wanted to summarize if obidoxime is a universal reactivator or if its reactivation potency in case of some organophosphorus inhibitors is limited. METHOD: Using our in vitro method, rat brain AChE was inhibited by eleven organophosphorus AChE inhibitors and then reactivated by obidoxime. RESULTS AND CONCLUSION: It was found that obidoxime could not be termed as universal antidote. Due to this, development of new promising candidates as replacement of obidoxime is recommended.
References provided by Crossref.org
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