Assembly of a large Y-STR haplotype database for the Czech population and investigation of its substructure
Language English Country Netherlands Media print
Document type Journal Article
PubMed
20215022
DOI
10.1016/j.fsigen.2009.06.005
PII: S1872-4973(09)00096-9
Knihovny.cz E-resources
- MeSH
- Databases, Nucleic Acid * MeSH
- DNA Fingerprinting MeSH
- Haplotypes * MeSH
- Humans MeSH
- Chromosomes, Human, Y * MeSH
- Polymerase Chain Reaction MeSH
- Genetics, Population * MeSH
- Tandem Repeat Sequences * MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
- Geographicals
- Czech Republic MeSH
Twelve Y-chromosomal short tandem repeats (Y-STR) (DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS385a, DYS385b, DYS437, DYS438, and DYS439) included in the PowerPlex Y Kit (Promega Corporation, Madison, USA) were studied for 1750 unrelated males living in 14 regions of the Czech Republic. A total of 1148 different haplotypes were found. The overall haplotype diversity (HD) was determined as 0.998. Analysis of Molecular Variance (AMOVA) reveals non-significant distances between regions concerning their haplotype distribution, thus allowing to use the whole sample as a representative reference database of the Czech Republic. Median network analysis shows a remarkable bipartite composition of the Czech haplotypes, falling in distinct clusters with Eastern and Western European roots.
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