Assembly of a large Y-STR haplotype database for the Czech population and investigation of its substructure
Jazyk angličtina Země Nizozemsko Médium print
Typ dokumentu časopisecké články
PubMed
20215022
DOI
10.1016/j.fsigen.2009.06.005
PII: S1872-4973(09)00096-9
Knihovny.cz E-zdroje
- MeSH
- databáze nukleových kyselin * MeSH
- DNA fingerprinting MeSH
- haplotypy * MeSH
- lidé MeSH
- lidský chromozom Y * MeSH
- polymerázová řetězová reakce MeSH
- populační genetika * MeSH
- tandemové repetitivní sekvence * MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Česká republika MeSH
Twelve Y-chromosomal short tandem repeats (Y-STR) (DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS385a, DYS385b, DYS437, DYS438, and DYS439) included in the PowerPlex Y Kit (Promega Corporation, Madison, USA) were studied for 1750 unrelated males living in 14 regions of the Czech Republic. A total of 1148 different haplotypes were found. The overall haplotype diversity (HD) was determined as 0.998. Analysis of Molecular Variance (AMOVA) reveals non-significant distances between regions concerning their haplotype distribution, thus allowing to use the whole sample as a representative reference database of the Czech Republic. Median network analysis shows a remarkable bipartite composition of the Czech haplotypes, falling in distinct clusters with Eastern and Western European roots.
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