Mucositis does not lead to false-positivity of the Platelia Aspergillus enzyme-linked immunosorbent assay
Language English Country Germany Media print-electronic
Document type Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Aspergillus immunology isolation & purification MeSH
- Aspergillosis diagnosis MeSH
- Adult MeSH
- Enzyme-Linked Immunosorbent Assay methods MeSH
- False Positive Reactions * MeSH
- Feces microbiology MeSH
- Middle Aged MeSH
- Humans MeSH
- Mucositis complications MeSH
- Aged MeSH
- Sensitivity and Specificity MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Evaluation Study MeSH
- Research Support, Non-U.S. Gov't MeSH
We are reporting a study evaluating the crossover of antigens reacting in Platelia Aspergillus (PA) enzyme-linked immunosorbent assay (ELISA) from faeces to vessels during mucositis as a possible cause of false-positivity of this test. In our series of 102 episodes of different grades of mucositis, we found strong reactivity of faeces in the PA ELISA test irrespective of the grade of mucositis, the percentage of oral food intake or the presence of total parenteral nutrition. However, none of the patients included in the study were positive in the serum (when the criterion of two samples with cut-off index of positivity [IP] > 0.5 was used).
See more in PubMed
Clin Infect Dis. 2006 May 15;42(10):1417-27 PubMed
Lancet Infect Dis. 2004 Jun;4(6):349-57 PubMed
Clin Infect Dis. 2002 Jan 1;34(1):7-14 PubMed
J Infect Dis. 2002 Nov 1;186(9):1297-306 PubMed
J Clin Microbiol. 2004 Oct;42(10):4744-8 PubMed
J Clin Microbiol. 2007 Sep;45(9):3141-2 PubMed
Transpl Infect Dis. 2002 Jun;4(2):64-5 PubMed
Mycoses. 1997 Dec;40(9-10):353-7 PubMed
J Clin Oncol. 2002 Apr 1;20(7):1898-906 PubMed
J Clin Microbiol. 2005 Aug;43(8):3925-31 PubMed
