Synthesis and biological activity of glycosyl-1H-1,2,3-triazoles
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
20542427
DOI
10.1016/j.bmcl.2010.04.151
PII: S0960-894X(10)00636-0
Knihovny.cz E-resources
- MeSH
- Hydrolysis MeSH
- Rats MeSH
- Humans MeSH
- Triazoles chemical synthesis pharmacology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Triazoles MeSH
Glycosyl 1,2,3-triazoles with alpha-D-gluco, beta-D-gluco, alpha-D-galacto, beta-D-galacto and beta-2-acetamido-2-deoxygluco (GlcNAc) stereochemistry were prepared by reaction of the corresponding azides with vinyl acetate under microwave irradiation. The deprotected glucosyl and galactosyl triazoles did not display inhibitory activity against the tested glycosidases at 1 mM. Of the four fungal glycosidases evaluated, GlcNAc-triazole was found to be hydrolyzed by Talaromyces flavus CCF 2686 beta-N-acetylhexosaminidase. Beta-GlcNAc-triazole was furthermore established to act as a strong ligand of rat and human natural killer cell activating receptors.
Bioorg Med Chem Lett. 2013 Nov 15;23(22):6197 PubMed
References provided by Crossref.org
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