Changes of rat plasma total low molecular weight antioxidant level after tabun exposure and consequent treatment by acetylcholinesterase reactivators
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- acetylcholinesterasa krev MeSH
- antidota chemická syntéza farmakologie MeSH
- antioxidancia analýza MeSH
- atropin farmakologie MeSH
- cholinesterasové inhibitory toxicita MeSH
- krysa rodu Rattus MeSH
- molekulová hmotnost MeSH
- organofosfáty toxicita MeSH
- oxidační stres účinky léků MeSH
- oximy chemická syntéza farmakologie MeSH
- potkani Wistar MeSH
- reaktivátory cholinesterázy chemická syntéza farmakologie MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- acetylcholinesterasa MeSH
- antidota MeSH
- antioxidancia MeSH
- atropin MeSH
- cholinesterasové inhibitory MeSH
- organofosfáty MeSH
- oximy MeSH
- reaktivátory cholinesterázy MeSH
- tabun MeSH Prohlížeč
These experiments were performed on a rat model. The rats were divided into eight groups and consequently exposed to either a saline solution (control), atropine or a combination of atropine and tabun. The reactivation efficacy of the oximes was estimated on the rats exposed to tabun, atropine and a reactivator of AChE. The oximes HI-6, obidoxime, trimedoxime, K203 and KR-22836 were used as representative compounds of commonly available and new AChE reactivators. Besides the positive effect of the administered reactivators on blood AChE activity, the sizable modulation of low molecular weight antioxidant (LMWA) levels was also determined. The LMWA levels in the the animals treated with the oxime reactivators were decreased in comparison with the animals treated by atropine alone. It was found that the levels of LMWA returned to the level found in the control animals when either trimedoxime, K203 or KR-22836 were administered. The principle of oxime reactivator function and a novel insight into AChE activity regulation and oxidative stress is discussed.
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