DHA-1-producing Klebsiella pneumoniae in a teaching hospital in the Czech Republic
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
20624093
DOI
10.1089/mdr.2010.0030
Knihovny.cz E-resources
- MeSH
- Anti-Bacterial Agents pharmacology MeSH
- Bacterial Proteins biosynthesis genetics MeSH
- beta-Lactamases biosynthesis genetics MeSH
- Klebsiella Infections epidemiology microbiology MeSH
- Integrons genetics MeSH
- Klebsiella pneumoniae drug effects enzymology genetics MeSH
- Humans MeSH
- Microbial Sensitivity Tests MeSH
- Hospitals, Teaching * MeSH
- Plasmids genetics MeSH
- Electrophoresis, Gel, Pulsed-Field MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Czech Republic epidemiology MeSH
- Names of Substances
- AmpC beta-lactamases MeSH Browser
- Anti-Bacterial Agents MeSH
- Bacterial Proteins MeSH
- beta-Lactamases MeSH
Thirty-eight AmpC-producing Klebsiella pneumoniae isolates identified from January to October 2006 in a large teaching hospital in the Czech Republic were analyzed. The AmpC cephalosporinase was identified as DHA-1, encoded by a plasmid-located complex class 1 integron, previously observed in a K. pneumoniae isolate from the Parisian region. The DHA-1 expression was inducible, and although in two isolates with higher resistance, the induction effect was masked at the phenotypic level. All of the isolates belonged to the international K. pneumoniae clone sequence type 11, split into two disseminated pulsed-field gel electrophoresis types. This is the first report on enterobacteriaceae with acquired AmpCs in the Czech Republic and possibly the first description of organisms with DHA-1 in the Central and Eastern Europe.
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