Halogenation of N⁶-benzyladenosine decreases its cytotoxicity in human leukemia cells
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
20637856
DOI
10.1016/j.tiv.2010.07.010
PII: S0887-2333(10)00171-2
Knihovny.cz E-resources
- MeSH
- Adenosine analogs & derivatives chemistry toxicity MeSH
- Cytotoxins chemistry toxicity MeSH
- Halogenation MeSH
- Humans MeSH
- Cell Proliferation drug effects MeSH
- U937 Cells MeSH
- Cell Survival drug effects MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Adenosine MeSH
- Cytotoxins MeSH
- N(6)-benzyladenosine MeSH Browser
Cytotoxicity of two halogen derivatives of N⁶-benzyladenosine (BAPR), N⁶-(3-iodobenzyl)-adenosine (I-BAPR) and 2-chloro-N⁶-(3-iodobenzyl)-adenosine (Cl-I-BAPR), was tested in human leukemia U937 cell line. Our results revealed that their cytotoxicity was surprisingly low. I-BAPR and also Cl-I-BAPR induced cell death with morphological and biochemical hallmarks of apoptosis, although the number of apoptotic cells was significantly lower than that found for BAPR. Our data strongly suggested that the decreased cytotoxic effect of halogenated derivatives of N⁶-benzyladenosine was related to their reduced intracellular phosphorylation by adenosine kinase.
References provided by Crossref.org
N6-benzyladenosine derivatives as novel N-donor ligands of platinum(II) dichlorido complexes
