Halogenation of N⁶-benzyladenosine decreases its cytotoxicity in human leukemia cells
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
20637856
DOI
10.1016/j.tiv.2010.07.010
PII: S0887-2333(10)00171-2
Knihovny.cz E-zdroje
- MeSH
- adenosin analogy a deriváty chemie toxicita MeSH
- cytotoxiny chemie toxicita MeSH
- halogenace MeSH
- lidé MeSH
- proliferace buněk účinky léků MeSH
- U937 buňky MeSH
- viabilita buněk účinky léků MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- adenosin MeSH
- cytotoxiny MeSH
- N(6)-benzyladenosine MeSH Prohlížeč
Cytotoxicity of two halogen derivatives of N⁶-benzyladenosine (BAPR), N⁶-(3-iodobenzyl)-adenosine (I-BAPR) and 2-chloro-N⁶-(3-iodobenzyl)-adenosine (Cl-I-BAPR), was tested in human leukemia U937 cell line. Our results revealed that their cytotoxicity was surprisingly low. I-BAPR and also Cl-I-BAPR induced cell death with morphological and biochemical hallmarks of apoptosis, although the number of apoptotic cells was significantly lower than that found for BAPR. Our data strongly suggested that the decreased cytotoxic effect of halogenated derivatives of N⁶-benzyladenosine was related to their reduced intracellular phosphorylation by adenosine kinase.
Citace poskytuje Crossref.org
N6-benzyladenosine derivatives as novel N-donor ligands of platinum(II) dichlorido complexes
