Human papillomavirus in head and neck tumors: epidemiological, molecular and clinical aspects
Language English Country Austria Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
20640929
DOI
10.1007/s10354-010-0782-5
PII: 10.1007/s10354-010-0782-5
Knihovny.cz E-resources
- MeSH
- DNA Probes, HPV MeSH
- Genome, Viral MeSH
- Papillomavirus Infections diagnosis epidemiology genetics pathology MeSH
- Humans MeSH
- Human papillomavirus 6 genetics MeSH
- Cell Transformation, Neoplastic genetics pathology MeSH
- Otorhinolaryngologic Neoplasms diagnosis epidemiology genetics pathology MeSH
- Papillomavirus E7 Proteins genetics MeSH
- Prognosis MeSH
- Cross-Sectional Studies MeSH
- Risk Factors MeSH
- Carcinoma, Squamous Cell diagnosis epidemiology genetics pathology MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- DNA Probes, HPV MeSH
- Papillomavirus E7 Proteins MeSH
High-risk types of human papillomaviruses (HR HPV) play an important role in the etiology of a group of head and neck squamous cell cancers (HNSCC). This review is focused on epidemiological, molecular, and clinical aspects of HPV infection in head and neck cancer. High risk HPV DNA is being detected in a very different proportion of HNSCC with the highest prevalence in oropharynx. Patients with HPV-associated tumors are characterized by moderate tobacco and alcohol consumption. Some aspects of sexual behavior may represent a risk factor. Recently, it has been shown that HPV infection is spreading and the rising prevalence of HPV-positive tumors can probably be attributed to this epidemic. On molecular level the viral oncoproteins E6 and E7 were shown to be involved in oncogenesis. HPV-positive cancers have better prognosis and HPV status should be considered in clinical decision-making. The rising proportion of HPV-positive tumors underlines the importance of HPV vaccination also for the prevention of HNSCC.
See more in PubMed
J Clin Pathol. 2004 May;57(5):449-55 PubMed
J Med Virol. 2009 May;81(5):878-87 PubMed
J Clin Oncol. 2008 Feb 1;26(4):612-9 PubMed
Med Microbiol Immunol. 2003 Aug;192(3):129-32 PubMed
Clin Cancer Res. 2003 Jul;9(7):2620-6 PubMed
Cancer. 2005 May 1;103(9):1843-9 PubMed
Int J Cancer. 2003 Sep 10;106(4):553-8 PubMed
J Natl Cancer Inst. 2008 Feb 20;100(4):261-9 PubMed
Cancer. 2007 Oct 1;110(7):1429-35 PubMed
Arch Virol. 2006 Oct;151(10):1899-916 PubMed
Cancer Sci. 2007 Oct;98(10):1505-11 PubMed
Int J Cancer. 2000 May 20;89(3):300-4 PubMed
Clin Cancer Res. 2003 Dec 15;9(17):6469-75 PubMed
Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14152-7 PubMed
Cancer Epidemiol Biomarkers Prev. 2005 Feb;14(2):467-75 PubMed
Int J Cancer. 2007 Feb 15;120(4):825-32 PubMed
Carcinogenesis. 1992 Nov;13(11):1981-7 PubMed
Scand J Infect Dis. 2008;40(9):745-51 PubMed
Int J Cancer. 2006 Dec 1;119(11):2620-3 PubMed
J Clin Oncol. 2006 Feb 10;24(5):736-47 PubMed
BMJ. 1996 Mar 2;312(7030):537-9 PubMed
Clin Cancer Res. 2002 Apr;8(4):1093-100 PubMed
Clin Cancer Res. 2008 Jan 15;14(2):366-9 PubMed
Semin Oncol. 2004 Dec;31(6):744-54 PubMed
Int J Cancer. 2002 Nov 10;102(2):152-8 PubMed
N Engl J Med. 2007 May 10;356(19):1944-56 PubMed
Int J Cancer. 2008 Jun 15;122(12):2656-64 PubMed
J Natl Cancer Inst. 2003 Dec 3;95(23):1772-83 PubMed
Clin Cancer Res. 2009 Mar 1;15(5):1779-86 PubMed
J Natl Cancer Inst. 2008 Mar 19;100(6):407-20 PubMed
Hum Pathol. 1999 Oct;30(10):1221-5 PubMed
Cancer Lett. 2005 Feb 10;218(2):199-206 PubMed
Oral Oncol. 2008 Aug;44(8):812-5 PubMed
Int J Cancer. 2007 Dec 1;121(11):2465-72 PubMed
Eur J Cancer Prev. 2000 Dec;9(6):433-7 PubMed
Int J Cancer. 1998 Aug 31;77(5):689-94 PubMed
Cancer. 2001 Aug 15;92(4):805-13 PubMed
Eur Arch Otorhinolaryngol. 2008 Jul;265 Suppl 1:S75-82 PubMed
Int J Cancer. 2004 Feb 20;108(5):766-72 PubMed
J Infect Dis. 2009 May 1;199(9):1263-9 PubMed
J Natl Cancer Inst. 1998 Nov 4;90(21):1626-36 PubMed
Cancer Epidemiol Biomarkers Prev. 2008 Feb;17(2):421-7 PubMed
Oral Dis. 2005 May;11(3):181-5 PubMed
Cancer Res. 2004 Aug 1;64(15):5518-24 PubMed
J Infect Dis. 2000 Jun;181(6):1911-9 PubMed
Mol Oncol. 2007 Dec;1(3):350-5 PubMed
Eur J Clin Microbiol Infect Dis. 1999 Feb;18(2):126-32 PubMed
Oral Oncol. 2008 Feb;44(2):133-42 PubMed
Arch Otolaryngol Head Neck Surg. 2009 Nov;135(11):1126-32 PubMed
