Product of alaptide synthesis: determination of the absolute configuration
Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
20675091
DOI
10.1016/j.jpba.2010.07.007
PII: S0731-7085(10)00368-7
Knihovny.cz E-zdroje
- MeSH
- cirkulární dichroismus MeSH
- cyklické peptidy chemie MeSH
- konformace proteinů MeSH
- lidé MeSH
- neuropeptidy chemie MeSH
- optická otáčivost MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- cyclo(alanine-(1-amino-1-cyclopentane)carbonyl) MeSH Prohlížeč
- cyklické peptidy MeSH
- neuropeptidy MeSH
Alaptide is the active substance of the veterinary dermatological ointment ALAPTID and a potential drug in human medicine. Electronic circular dichroism spectroscopy (ECD), transparent spectral region optical rotation (OR), and ab initio calculations were employed to determine the absolute configuration of alaptide. No X-ray structural data determining the absolute configuration were available. It was not possible to employ vibrational circular dichroism spectroscopy (VCD), because alaptide was not sufficiently soluble in common solvents used in VCD spectroscopy to generate reliable spectra. Both ECD spectra and OR values of alaptide solution were in good agreement with predicted data and determined unambiguously the absolute configuration of alaptide synthesized from (S)-alanine as being (S).
Citace poskytuje Crossref.org
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