Selected immunohistochemical prognostic factors in endometrial cancer
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
20686376
DOI
10.1111/igc.0b013e3181d80ac4
PII: 00009577-201005000-00017
Knihovny.cz E-zdroje
- MeSH
- antigen Ki-67 metabolismus MeSH
- dospělí MeSH
- imunoenzymatické techniky MeSH
- invazivní růst nádoru MeSH
- lidé středního věku MeSH
- lidé MeSH
- matrixová metaloproteinasa 7 metabolismus MeSH
- metaloproteinasy secernované do matrix metabolismus MeSH
- nádorové biomarkery metabolismus MeSH
- nádorový supresorový protein p53 metabolismus MeSH
- nádory endometria metabolismus patologie MeSH
- papilární karcinom metabolismus patologie MeSH
- prognóza MeSH
- prospektivní studie MeSH
- protoonkogenní proteiny c-bcl-2 metabolismus MeSH
- receptor erbB-2 metabolismus MeSH
- receptory pro estrogeny metabolismus MeSH
- receptory progesteronu metabolismus MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- serózní cystadenokarcinom metabolismus patologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- antigen Ki-67 MeSH
- matrixová metaloproteinasa 7 MeSH
- metaloproteinasy secernované do matrix MeSH
- MMP26 protein, human MeSH Prohlížeč
- nádorové biomarkery MeSH
- nádorový supresorový protein p53 MeSH
- protoonkogenní proteiny c-bcl-2 MeSH
- receptor erbB-2 MeSH
- receptory pro estrogeny MeSH
- receptory progesteronu MeSH
- TP53 protein, human MeSH Prohlížeč
OBJECTIVE: The objectives of this study were to assess the immunohistochemical expression of p53, bcl-2, c-erbB-2, Ki-67, estrogen (ER) and progesterone (PR) receptors, matrix metalloproteinase-7 and -26 (MMP-7 and MMP-26) in endometrial cancer patients and to assess the relation between steroid receptor positivity and other markers. DESIGN: Experimental prospective study. SETTING: Department of Obstetrics and Gynecology, Department of Genetics, Department of Pathology, Palacký University Medical School and University Hospital Olomouc. METHODS: We studied 144 cases of primary untreated endometrial carcinoma in which the p53, bcl-2, c-erbB-2, Ki-67, ER, PR, MMP-7, and MMP-26 antigens were investigated with the use of immunohistochemical methods. We evaluated the correlations among immunohistochemical staining and the age, International Federation of Gynecology and Obstetrics stage, grading, depth of invasion, and metastatic spread to lymph nodes. RESULTS: Mean age was 65.7 years (range, 34-90 years). p53, bcl-2, c-erbB-2, Ki-67, ER, and PR were positive in 35 (24.3%), 100 (69.4%), 41 (28.4%), 65 (45.1%), 115 (79.8%), and 127 (88.1%) cases, respectively. Matrix metalloproteinases were evaluated in a group of 70 patients, wherein MMP-7 was positive in 33 patients (47.1%) and MMP-26 was positive in 40 patients (57.1%). The expression of MMP-7 decreased with higher patient age. p53 and Ki-67 overexpression was found to be related to poor differentiation. Immunostaining for bcl-2 correlated with the positivity of steroid receptors status, whereas immunostaining for c-erbB-2 correlated inversely with ER-positive group of cases. CONCLUSIONS: The overexpression of p53 and Ki-67 seems to indicate a more malignant phenotype, whereas bcl-2 expression in dependence of steroid receptor positivity could contribute to the identification of high-risk tumors.
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