High-performance liquid chromatography analysis of by-products and intermediates arising during the synthesis of the acetylcholinesterase reactivator HI-6
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články
- MeSH
- katalýza MeSH
- oximy * chemická syntéza chemie MeSH
- pyridinové sloučeniny * chemická syntéza chemie MeSH
- reaktivátory cholinesterázy chemická syntéza chemie MeSH
- vysokoúčinná kapalinová chromatografie metody MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- asoxime chloride MeSH Prohlížeč
- oximy * MeSH
- pyridinové sloučeniny * MeSH
- reaktivátory cholinesterázy MeSH
An high-performance liquid chromatography (HPLC) method for identification of quaternary and non-quaternary compounds (parent compounds, intermediates, by-products, and products) within the synthesis of the acetylcholinesterase reactivator HI-6, the most promising antidote of nerve agent poisonings, is described. This HPLC method could be of high interest as a quick purity control for those who are interested in development of new acetylcholinesterase reactivators as well as for those who are interested in the synthesis of HI-6 in laboratory or in large-scale production. An HPLC method for quaternary compounds without using common ion-pairing reagents was developed, too.
Citace poskytuje Crossref.org
