Potassium-selective microelectrode revealed difference in threshold potassium concentration for cortical spreading depression in female and male rat brain
Language English Country Netherlands Media print-electronic
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
21075087
DOI
10.1016/j.brainres.2010.11.018
PII: S0006-8993(10)02502-3
Knihovny.cz E-resources
- MeSH
- Potassium metabolism MeSH
- Electrophysiology instrumentation methods MeSH
- Rats MeSH
- Microelectrodes MeSH
- Brain Chemistry physiology MeSH
- Cerebral Cortex drug effects metabolism physiopathology MeSH
- Sex Characteristics * MeSH
- Cortical Spreading Depression drug effects physiology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- Potassium MeSH
It has been found with potassium-selective microelectrodes that the threshold extracellular concentration of potassium [K(+)](e) for eliciting fast spreading depression from the site of administration 1.5mm away is 80% lower in the rat female cortex (8.0 ± 0.6 mM) than in the male cortex (14.4 ± 0.4mM). The rate of the first slow phase of [K(+)](e) rise before reaching the threshold and speed of SD propagation were similar for both sexes as well as the rise of the second active fast phase of the [K(+)](e) increase. Lower [K(+)](e) threshold in females can facilitate the rapid K(+) release from the nerve tissue cells that may cause a cerebrovascular vasodilatation and the attack of migraine pain.
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