Potassium-selective microelectrode revealed difference in threshold potassium concentration for cortical spreading depression in female and male rat brain

. 2011 Jan 25 ; 1370 () : 215-9. [epub] 20101112

Jazyk angličtina Země Nizozemsko Médium print-electronic

Typ dokumentu srovnávací studie, časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/pmid21075087
Odkazy

PubMed 21075087
DOI 10.1016/j.brainres.2010.11.018
PII: S0006-8993(10)02502-3
Knihovny.cz E-zdroje

It has been found with potassium-selective microelectrodes that the threshold extracellular concentration of potassium [K(+)](e) for eliciting fast spreading depression from the site of administration 1.5mm away is 80% lower in the rat female cortex (8.0 ± 0.6 mM) than in the male cortex (14.4 ± 0.4mM). The rate of the first slow phase of [K(+)](e) rise before reaching the threshold and speed of SD propagation were similar for both sexes as well as the rise of the second active fast phase of the [K(+)](e) increase. Lower [K(+)](e) threshold in females can facilitate the rapid K(+) release from the nerve tissue cells that may cause a cerebrovascular vasodilatation and the attack of migraine pain.

Citace poskytuje Crossref.org

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