Structural basis for DNA recognition by FOXO proteins
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
21146564
DOI
10.1016/j.bbamcr.2010.11.025
PII: S0167-4889(10)00311-3
Knihovny.cz E-resources
- MeSH
- DNA chemistry metabolism MeSH
- Forkhead Box Protein O1 MeSH
- Forkhead Transcription Factors chemistry metabolism MeSH
- Nucleic Acid Conformation * MeSH
- Humans MeSH
- Molecular Sequence Data MeSH
- Amino Acid Sequence MeSH
- Sequence Homology, Amino Acid MeSH
- Protein Structure, Tertiary * MeSH
- Protein Binding MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- DNA MeSH
- Forkhead Box Protein O1 MeSH
- Forkhead Transcription Factors MeSH
- FOXO1 protein, human MeSH Browser
The FOXO forkhead transcription factors are involved in metabolism control, cell survival, cellular proliferation, DNA damage repair response, and stress resistance. Their transcriptional activity is regulated through a number of posttranslational modifications, including phosphorylation, acetylation and ubiquitination. The recently determined three-dimensional structures of FOXO forkhead domains bound to DNA enable to explain the structural basis for DNA recognition by FOXO proteins and its regulation. The aim of this review is to summarize the recent structural characterization of FOXO proteins, the mechanisms of DNA recognition and the role of posttranslational modifications in the regulation of FOXO DNA-binding properties. This article is part of a Special Issue entitled: PI3K-AKT-FOXO axis in cancer and aging.
References provided by Crossref.org
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