Suture-free anastomosis of the colon. Experimental comparison of two cyanoacrylate adhesives
Language English Country Netherlands Media print-electronic
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
21229329
DOI
10.1007/s11605-010-1370-0
PII: S1091-255X(23)05909-7
Knihovny.cz E-resources
- MeSH
- Tissue Adhesions MeSH
- Anastomosis, Surgical methods MeSH
- Colon, Sigmoid pathology surgery MeSH
- Surgical Wound Dehiscence MeSH
- Wound Healing MeSH
- Cyanoacrylates * MeSH
- Swine MeSH
- Tissue Adhesives * MeSH
- Inflammation MeSH
- Animals MeSH
- Check Tag
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- glubran 2 MeSH Browser
- Cyanoacrylates * MeSH
- octyl 2-cyanoacrylate MeSH Browser
- Tissue Adhesives * MeSH
BACKGROUND: We explored the potential of two cyanoacrylate tissue adhesives for constructing colonic anastomoses. METHOD: The study involved 12 female domestic pigs. The animals were divided into two equal groups. In both groups, the sigmoid colon was transected. An intestinal anastomosis was constructed with a modified circular stapler (all staples were withdrawn) and cyanoacrylate tissue adhesives. Glubran 2 was used in group A and Dermabond was applied in group B. Fourteen days after the first operation, a follow-up surgery was performed in both groups. The glued section of the colon was resected, processed with the standard paraffin technique and stained with haematoxylin-eosin. The finished specimens were examined under light microscopy. Assessments were made for the presence of fibroblasts, neutrophils, giant polynuclear cells, neovascularisation and collagen deposits. Adhesions, anastomotic dehiscence, peri-anastomotic inflammation and intestinal healing were assessed peri-operatively. RESULTS: All anastomoses in group A healed with no signs of pathology. In group B, fibrotic adhesions and stenoses tended to occur in areas surrounding the anastomoses. Histological examinations confirmed increased fibrosis. CONCLUSION: The tissue adhesive Glubran 2 appears to be (under experimental conditions) a promising synthetic adhesive for colonic anastomosis construction; conversely, the tissue adhesive Dermabond was unsuitable for suture-free anastomosis construction.
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