Cytotoxicity and effects on inflammatory response of modified types of cellulose in macrophage-like THP-1 cells
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
21354485
DOI
10.1016/j.intimp.2011.02.016
PII: S1567-5769(11)00107-X
Knihovny.cz E-resources
- MeSH
- Leukemia, Monocytic, Acute MeSH
- Cell Growth Processes drug effects MeSH
- Cellulose analogs & derivatives pharmacology MeSH
- Wound Healing drug effects immunology MeSH
- Humans MeSH
- Lipopolysaccharides pharmacology MeSH
- Macrophages drug effects immunology MeSH
- Cell Line, Tumor MeSH
- Tumor Necrosis Factor-alpha biosynthesis genetics MeSH
- Tristetraprolin biosynthesis genetics MeSH
- Inflammation drug therapy immunology pathology MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Cellulose MeSH
- Lipopolysaccharides MeSH
- Tumor Necrosis Factor-alpha MeSH
- Tristetraprolin MeSH
- ZFP36 protein, human MeSH Browser
The cytotoxicity and in vitro effects of six variously modified types of cellulose (OC--oxidized cellulose, NaOC--oxidized cellulose sodium salt, DAC--dialdehyde cellulose, CMC--carboxymethyl cellulose, MFC--microfibrilated cellulose, and MCC--microcrystalline cellulose) on the inflammatory response in macrophage-like THP-1 cells were examined, with special focus on their ability to influence gene expression and the production of TNF-α. The study provides evidence that DAC exerts a marked effect on the induction of TNF-α gene expression and its subsequent production in human macrophages. Thus, the use of DAC for anti-hemorrhagic or wound-healing therapy should be considered carefully with regard to its pro-inflammatory activity. On the contrary, MCC showed significant anti-inflammatory effects in the LPS-induced conditions, which might be beneficial for the treatment of non-healing chronic wounds, e.g., diabetic or venous ulcers.
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