New S-benzylisothiosemicarbazones with antimycobacterial activity
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Antitubercular Agents chemistry pharmacology MeSH
- Phenols chemistry pharmacology MeSH
- Humans MeSH
- Mycobacterium avium drug effects MeSH
- Mycobacterium kansasii drug effects MeSH
- Mycobacterium tuberculosis drug effects MeSH
- Thiosemicarbazones chemistry pharmacology MeSH
- Tuberculosis microbiology MeSH
- Structure-Activity Relationship MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Antitubercular Agents MeSH
- Phenols MeSH
- Thiosemicarbazones MeSH
Benzaldehyde- and salicylaldehyde-S-benzylisothiosemicarbazones show a moderate to high in vitro activity against Mycobacterium tuberculosis, Mycobacterium avium and two strains of Mycobacterium kansasii. Benzaldehyde-S-4-bromobenzylisothiosemicarbazone and salicylaldehyde-S-4-chlorobenzylisothiosemicarbazone have the most promising antimycobacterial properties.
See more in PubMed
Ceska Slov Farm. 2002 Jan;51(1):26-36 PubMed
N Engl J Med. 1996 Aug 8;335(6):377-83 PubMed
Am J Respir Crit Care Med. 2001 Apr;163(5):1055-8 PubMed
J Infect Dis. 2006 Aug 15;194(4):479-85 PubMed
Pharmazie. 1977 Dec;32(12):752-6 PubMed
Clin Microbiol Infect. 2004 May;10(5):388-98 PubMed
Folia Microbiol (Praha). 2005;50(6):479-81 PubMed
