Fe/Mn superoxide dismutase-encoding gene in Paracoccus denitrificans is induced by azide and expressed independently of the FNR-type regulators
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Azides metabolism MeSH
- Bacterial Proteins genetics metabolism MeSH
- Molecular Sequence Data MeSH
- Paracoccus denitrificans enzymology genetics MeSH
- Gene Expression Regulation, Enzymologic * MeSH
- Gene Expression Regulation, Bacterial MeSH
- Genes, Regulator * MeSH
- Amino Acid Sequence MeSH
- Superoxide Dismutase genetics metabolism MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Azides MeSH
- Bacterial Proteins MeSH
- Superoxide Dismutase MeSH
Paracoccus denitrificans cells undergo changes in protein composition upon exposure to azide, a known activator of the fumarate-nitrate reduction (FNR)-type transcription factor NarR. One of the most prominent protein species inducible by azide is a Fe/Mn-family superoxide dismutase (SOD). Azide induces SOD at protein, mRNA transcript, and enzyme activity levels in the aerobically growing cells. Since SOD expression remains unaffected in the fnrP-, nnr-, and narR-mutant strains, we postulate a mechanism independent of the known FNR-type regulators but involving a redox signal arising from the respiratory chain.
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