Bone-seeking probes for optical and magnetic resonance imaging
Language English Country England, Great Britain Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
21426179
DOI
10.4155/fmc.09.162
Knihovny.cz E-resources
- MeSH
- Fluorescent Dyes chemistry metabolism MeSH
- Bone and Bones cytology metabolism MeSH
- Metals chemistry MeSH
- Humans MeSH
- Magnetic Resonance Imaging methods MeSH
- Molecular Structure MeSH
- Molecular Imaging methods MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Fluorescent Dyes MeSH
- Metals MeSH
In clinical practice the imaging of bone tissue is based almost exclusively on x-ray or radiochemical methods. Alternative methods, such as MRI and optical imaging, can provide not only anatomical, but also physiological information, due to their ability to reflect the properties of body fluids (temperature, pH and concentration of ions). In this article we review bone targeting probes for MRI and fluorescence imaging. As bone targeting is mainly associated with phosphonate and bisphosphonate derivatives, we also focus on their sorption behavior. Also discussed in detail is the limitation of using bone-targeting probes for MRI and optical imaging mainly due to their long-time retention in bone tissue and the low permeability of tissues for light.
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