Intracellular cytokine production in peripheral blood lymphocytes: a comparison of values in infertile and fertile women
Language English Country Denmark Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Cytokines biosynthesis blood MeSH
- Adult MeSH
- Fertility immunology MeSH
- Interferon-gamma biosynthesis blood MeSH
- Interleukin-2 biosynthesis blood MeSH
- Interleukin-4 biosynthesis blood MeSH
- Humans MeSH
- Flow Cytometry MeSH
- T-Lymphocytes, Helper-Inducer immunology metabolism MeSH
- Pregnancy immunology MeSH
- Tumor Necrosis Factor-alpha biosynthesis blood MeSH
- Infertility, Female immunology physiopathology MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Pregnancy immunology MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Cytokines MeSH
- Interferon-gamma MeSH
- Interleukin-2 MeSH
- Interleukin-4 MeSH
- Tumor Necrosis Factor-alpha MeSH
PROBLEM: To analyze the relation of the fertility and pregnancy of women of childbearing age to the intracellular (IC) production of tumor necrosis factor alpha (TNF-α), interferon gamma (IFN-γ), and interleukins 2 and 4 (IL-2 and IL-4). METHOD OF STUDY: Intracellular cytokine production in peripheral blood CD3(+) CD4(+) lymphocytes was analyzed by flow cytometry in 185 women being treated for infertility and 50 fertile women of childbearing age. RESULTS: Infertile women have a significantly higher IC production of TNF-α, IFN-γ, IL-2, and IL-4 and higher ratios of TNF-α/IL-2, TNF-α/IL-4, and TNF-α/IFN-γ compared to the fertile women. CONCLUSION: Cytokines produced by Th lymphocytes are important in orchestrating the immune response during conception, and Th-cell dysregulation could be a reason for infertility.
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