Intracellular cytokine production in peripheral blood lymphocytes: a comparison of values in infertile and fertile women
Jazyk angličtina Země Dánsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- cytokiny biosyntéza krev MeSH
- dospělí MeSH
- fertilita imunologie MeSH
- interferon gama biosyntéza krev MeSH
- interleukin-2 biosyntéza krev MeSH
- interleukin-4 biosyntéza krev MeSH
- lidé MeSH
- průtoková cytometrie MeSH
- T-lymfocyty pomocné-indukující imunologie metabolismus MeSH
- těhotenství imunologie MeSH
- TNF-alfa biosyntéza krev MeSH
- ženská infertilita imunologie patofyziologie MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- těhotenství imunologie MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- cytokiny MeSH
- interferon gama MeSH
- interleukin-2 MeSH
- interleukin-4 MeSH
- TNF-alfa MeSH
PROBLEM: To analyze the relation of the fertility and pregnancy of women of childbearing age to the intracellular (IC) production of tumor necrosis factor alpha (TNF-α), interferon gamma (IFN-γ), and interleukins 2 and 4 (IL-2 and IL-4). METHOD OF STUDY: Intracellular cytokine production in peripheral blood CD3(+) CD4(+) lymphocytes was analyzed by flow cytometry in 185 women being treated for infertility and 50 fertile women of childbearing age. RESULTS: Infertile women have a significantly higher IC production of TNF-α, IFN-γ, IL-2, and IL-4 and higher ratios of TNF-α/IL-2, TNF-α/IL-4, and TNF-α/IFN-γ compared to the fertile women. CONCLUSION: Cytokines produced by Th lymphocytes are important in orchestrating the immune response during conception, and Th-cell dysregulation could be a reason for infertility.
Citace poskytuje Crossref.org
