Glycosidases in carbohydrate synthesis: when organic chemistry falls short
Language English Country Switzerland Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
- MeSH
- Glycoside Hydrolases chemistry metabolism MeSH
- Molecular Structure MeSH
- Chemistry, Organic MeSH
- Carbohydrates biosynthesis chemistry MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Glycoside Hydrolases MeSH
- Carbohydrates MeSH
Thanks to the stability, good availability, stereoselectivity and broad substrate specificity, oligosaccharide synthesis catalyzed by glycosidases represents an elegant way to complex carbohydrate structures. Two approaches to glycosidase catalysis are presented: (i) the use of structurally modified substrates that carry various functional moieties in the molecule, and (ii) the design of mutant glycosidases void of hydrolytic activity. Products of glycosidase-catalyzed synthesis are applicable in a range of areas such as immunology, therapy of Alzheimer's or Parkinson's diseases and the synthesis of neoglycoproteins.
References provided by Crossref.org
Transglycosylation abilities of β-d-galactosidases from GH family 2
The β-N-Acetylhexosaminidase in the Synthesis of Bioactive Glycans: Protein and Reaction Engineering
Biocompatible glyconanomaterials based on HPMA-copolymer for specific targeting of galectin-3
"Sweet Flavonoids": Glycosidase-Catalyzed Modifications
