Immunocytochemical demonstration of M(1) muscarinic acetylcholine receptors at the presynaptic and postsynaptic membranes of rat diaphragm endplates
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
21469909
DOI
10.33549/physiolres.932131
PII: 932131
Knihovny.cz E-resources
- MeSH
- Diaphragm innervation MeSH
- Immunohistochemistry MeSH
- Rats MeSH
- Motor Endplate metabolism ultrastructure MeSH
- Neuromuscular Junction metabolism MeSH
- Synaptic Transmission physiology MeSH
- Presynaptic Terminals metabolism ultrastructure MeSH
- Receptors, Muscarinic metabolism MeSH
- Synaptic Membranes metabolism MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Receptors, Muscarinic MeSH
M(1)-muscarinic acetylcholine (ACh) receptors (M(1)R) were directly demonstrated immunocytochemically in electronmicroscopic images of rat diaphragm neuromuscular junctions (NMJ). Specific electron-dense granules were located at presynaptic nerve ending membranes and in the sarcolemma in the depths of postsynaptic folds. This first visualization of M(1)R on both sides of the NMJ is in agreement with previous pharmacological data on the regulatory role of M(1)R in quantal and non-quantal ACh release.
References provided by Crossref.org
From Frog Muscle to Brain Neurons: Joys and Sorrows in Neuroscience
