Effect of high phosphorus diet on tooth microstructure of rodent incisors
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
21571111
DOI
10.1016/j.bone.2011.04.021
PII: S8756-3282(11)00943-4
Knihovny.cz E-zdroje
- MeSH
- dentin patologie ultrastruktura MeSH
- fosfor dietní metabolismus MeSH
- hlodavci anatomie a histologie růst a vývoj metabolismus MeSH
- hypoplazie zubní skloviny patologie MeSH
- lidé MeSH
- náhodné rozdělení MeSH
- odontogeneze fyziologie MeSH
- řezáky účinky léků růst a vývoj ultrastruktura MeSH
- vápník dietní metabolismus farmakologie MeSH
- zubní sklovina patologie ultrastruktura MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- fosfor dietní MeSH
- vápník dietní MeSH
Enamel hypoplasia and disruption of dentinogenesis are the most common abnormalities of development and mineralization of human teeth. Several reports are available in the literature on the influence of dietary calcium on the formation of human and rodent tooth; however, the information about the influence of dietary phosphorus on the tooth formation is scarce. The aim of the present investigation was to examine the chronic effect of high phosphorus diet and improper dietary calcium to phosphorus ratio on the mandibular incisor microstructure in a hystricomorph rodent--Octodon degu--using macroscopic observation, histopathological examination, transmission and scanning electron microscopy. The present study shows that enamel and dentin development is disturbed under high phosphorus diet and improper calcium to phosphorus ratio. Disturbed mineral metabolism resulted in enamel depigmentation, enamel hypoplasia, enamel pitting and altered dentin morphology. The results suggest that more attention should be focused on dietary phosphorus content when facing altered tooth structure in young patients with deciduous or permanent dentition. Furthermore, we showed that degus can be used as an experimental animal model for the study of the developmental teeth disturbances.
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