The association between subclinical atherosclerosis in carotid arteries and Connexin 37 gene polymorphism (1019C>T; Pro319Ser) in women
Language English Country Italy Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
21617605
PII: R34112539
Knihovny.cz E-resources
- MeSH
- Carotid Arteries diagnostic imaging MeSH
- Asymptomatic Diseases MeSH
- Adult MeSH
- Phenotype MeSH
- Gene Frequency MeSH
- Genetic Predisposition to Disease MeSH
- Risk Assessment MeSH
- Polymorphism, Single Nucleotide * MeSH
- Connexins genetics MeSH
- Blood Glucose analysis MeSH
- Middle Aged MeSH
- Humans MeSH
- Urban Population MeSH
- Carotid Artery Diseases blood diagnostic imaging genetics prevention & control MeSH
- Fasting blood MeSH
- Gap Junction alpha-4 Protein MeSH
- Cross-Sectional Studies MeSH
- Risk Factors MeSH
- Chi-Square Distribution MeSH
- Aged MeSH
- Sex Factors MeSH
- Ultrasonography MeSH
- Rural Population MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Czech Republic MeSH
- Names of Substances
- Connexins MeSH
- Blood Glucose MeSH
AIM: The aim of our study was to evaluate a possible association between subclinical atherosclerosis in carotid arteries and the connexin 37 gene polymorphism (1019C>T; Pro319Ser) in a population of urban and rural women. METHODS: A 5% population sample of urban women aged 45-54 years (N.=896) and a 1% representative sample of rural women aged 33-72 years (N.=152) were examined using an identical protocol and genotyped for Cx37 gene polymorphism. The association between the Cx37 polymorphism and intima-media thickness in common carotid arteries measured by ultrasound (CIMT) was studied. RESULTS: We have found a different pattern of the effect of the Cx37 gene on CIMT with regard to fasting glycemia with significant interaction between fasting glycemia and Cx37 gene on CIMT (test for equality of slopes P<0.0001). In addition, we also detected potential threshold effect of fasting glycemia at the concentration of 5.5 mmol/L (ANCOVA; P=0.026). Carriers of TT genotype showed protection against subclinical atherosclerosis if their fasting glycemia was above 5.5 mmol/L. CONCLUSION: In women with higher fasting glycemia TT genotype of Cx37 polymorphism was protective against subclinical atherosclerosis. Therefore, the Cx37 gene may exert completely different effects in the artery wall, depending on glycemia.
