Hydroxylation modification and free radical scavenging activity of puerarin-7-O-fructoside
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Biotransformation MeSH
- Fructose analogs & derivatives chemistry metabolism MeSH
- Glycosylation MeSH
- Hydroxylation MeSH
- Isoflavones chemistry metabolism MeSH
- Free Radical Scavengers chemistry metabolism MeSH
- Trichoderma metabolism MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Fructose MeSH
- Isoflavones MeSH
- puerarin-7-O-fructoside MeSH Browser
- Free Radical Scavengers MeSH
Puerarin-7-O-fructoside was transformed by Trichoderma harzianum CGMCC 1523 into 3'-hydroxypuerarin-7-O-fructoside; this was identified by MS and NMR. However, puerarin-7-O-glucoside was not directly hydroxylated but hydrolyzed back into puerarin, which was transformed into 3'-hydroxypuerarin by the same fungi. Comparative analysis of free radical scavenging activity of DPPH showed that the free radical scavenging activity of puerarin-7-O-glucoside was reduced to approximately 1/2 of that of puerarin, while the free radical scavenging activity of puerarin-7-O-fructoside was increased to approximately 1.5 times of that of puerarin. The free radical scavenging activity of 3'-hydroxypuerarin-7-O-fructoside was further increased by 2.2 times of that of puerarin-7-O-fructoside, which was close to that of 3'-hydroxypuerarin.
See more in PubMed
Free Radic Biol Med. 1997;22(5):749-60 PubMed
Carbohydr Res. 2004 Dec 6;339(17):2789-97 PubMed
Trends Microbiol. 2007 May;15(5):219-32 PubMed
Curr Opin Chem Biol. 2004 Apr;8(2):106-13 PubMed
Free Radic Res Commun. 1987;2(4-6):289-94 PubMed
J Med Food. 2004 Summer;7(2):180-6 PubMed
Appl Microbiol Biotechnol. 2010 Apr;86(3):863-70 PubMed
Eur J Pharmacol. 2008 Jan 14;578(2-3):159-70 PubMed
J Pharm Biomed Anal. 2006 May 3;41(2):549-53 PubMed
Methods Enzymol. 1990;186:343-55 PubMed
Biochem Pharmacol. 1988 Mar 1;37(5):837-41 PubMed
Curr Med Chem. 2001 Sep;8(11):1303-28 PubMed
Nutr Rev. 1992 Jul;50(7):207-13 PubMed
J Agric Food Chem. 1999 Sep;47(9):3669-74 PubMed
Appl Microbiol Biotechnol. 2008 Dec;81(4):647-57 PubMed
FEMS Microbiol Lett. 2006 May;258(2):263-8 PubMed
Curr Opin Chem Biol. 2006 Jun;10(3):263-71 PubMed
