A comparison of the acute effects of calcium and strontium ranelate on the serum marker of bone resorption
Language English Country Germany Media electronic
Document type Clinical Trial, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
22080821
DOI
10.1515/cclm.2011.781
PII: /j/cclm.2012.50.issue-2/cclm.2011.781/cclm.2011.781.xml
Knihovny.cz E-resources
- MeSH
- Administration, Oral MeSH
- Biomarkers blood MeSH
- Adult MeSH
- Collagen Type I blood MeSH
- Humans MeSH
- Young Adult MeSH
- Fasting MeSH
- Organometallic Compounds blood pharmacology MeSH
- Parathyroid Hormone blood MeSH
- Peptides blood MeSH
- Reference Standards MeSH
- Gene Expression Regulation drug effects MeSH
- Bone Resorption blood MeSH
- Thiophenes blood pharmacology MeSH
- Calcium blood pharmacology MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Young Adult MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Clinical Trial MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- Biomarkers MeSH
- collagen type I trimeric cross-linked peptide MeSH Browser
- Collagen Type I MeSH
- Organometallic Compounds MeSH
- Parathyroid Hormone MeSH
- Peptides MeSH
- strontium ranelate MeSH Browser
- Thiophenes MeSH
- Calcium MeSH
BACKGROUND: To investigate the mechanism by which strontium ranelate (SrR) inhibits the bone resorption, this study compared the effects of SrR and calcium on parathyroid hormone (PTH) and the biochemical marker of bone resorption (serum type 1 collagen cross-linked C-telopeptide, βCTX). METHODS: In 10 healthy young subjects, after overnight fasting, 1000 mg of elemental calcium and 2000 mg of SrR containing 600 mg Sr²⁺ were administered consecutively with a 1 week washout period. During the control period no drug was given. Fasting blood samples were drawn at baseline and throughout the next 5-h period. RESULTS: After the ingestion of either calcium or SrR, there was a significant increase in serum calcium and strontium concentrations, and a decrease in serum βCTX and intact PTH concentrations as compared to the baseline values (p<0.05). In the fasting subjects, no significant differences in the variable were found as compared to the baseline values. CONCLUSIONS: The decrease in PTH and the marker of bone resorption observed after the SrR administration is comparable to the decrease observed after the calcium administration in young adults.
References provided by Crossref.org
Strontium ranelate: in search for the mechanism of action
