Magnesium azaphthalocyanines: an emerging family of excellent red-emitting fluorophores
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
22409604
DOI
10.1021/ic2027016
Knihovny.cz E-zdroje
- MeSH
- fluorescence MeSH
- fluorescenční barviva chemická syntéza MeSH
- fluorescenční spektrometrie MeSH
- furany chemie MeSH
- hořčík chemie MeSH
- indoly chemická syntéza MeSH
- isoindoly MeSH
- kvantová teorie MeSH
- molekulární struktura MeSH
- singletový kyslík MeSH
- voda chemie MeSH
- zinek chemie MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- fluorescenční barviva MeSH
- furany MeSH
- hořčík MeSH
- indoly MeSH
- isoindoly MeSH
- phthalocyanine MeSH Prohlížeč
- singletový kyslík MeSH
- tetrahydrofuran MeSH Prohlížeč
- voda MeSH
- zinek MeSH
Magnesium(II), zinc(II), and metal-free phthalocyanines (Pcs) and azaphthalocyanines (AzaPcs) containing alkylsulfanyl, aryloxy, and dialkylamino peripheral substituents have been synthesized. The complexation of magnesium(II) by metal-free Pcs and AzaPcs has been studied in detail to determine the optimal reaction conditions necessary to ensure a complete conversion. Photophysical and photochemical measurements in tetrahydrofuran showed that magnesium(II) AzaPcs with aryloxy and alkylsulfanyl substituents have excellent fluorescent properties (Φ(F) up to 0.73) and that the corresponding zinc(II) Pcs are efficient singlet oxygen producers (Φ(Δ) up to 0.68). The presence of dialkylamino substituents causes intramolecular charge transfer within the molecule that competes with fluorescence and singlet oxygen formation. Alkylsulfanyl MgAzaPc and ZnAzaPc were the most photostable compounds among the series of studied derivatives. In addition, high molar absorption coefficients (ε ∼ 300,000 M(-1) cm(-1)), absorption (λ(max) ∼ 650 nm), and emission (λ(em) ∼ 660 nm, high Φ(F)) in the red region suggest that these molecules are potential fluorescent probes that are superior to the commercial red cyanine dye Cy5. MgAzaPc, when incorporated into lipidic bilayers of liposomes, maintains excellent fluorescence properties (Φ(F) = 0.64). Water-soluble MgAzaPc with quaternary ammonium peripheral substituents retained a high fluorescence quantum yield even in water (Φ(F) = 0.25). The described properties show that magnesium(II) AzaPcs are excellent red-emitting fluorophores with potential applications as fluorescent probes in sensing or in vitro imaging applications.
Citace poskytuje Crossref.org
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