A comparison of the potency of a novel bispyridinium oxime K203 and currently available oximes (obidoxime, HI-6) to counteract the acute neurotoxicity of sarin in rats
Language English Country Great Britain, England Media print-electronic
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Muscarinic Antagonists therapeutic use MeSH
- Antidotes adverse effects therapeutic use MeSH
- Atropine therapeutic use MeSH
- Autonomic Nervous System drug effects physiopathology MeSH
- Chemical Warfare Agents chemistry toxicity MeSH
- Cholinesterase Inhibitors chemistry toxicity MeSH
- Drug Therapy, Combination MeSH
- Rats MeSH
- Lethal Dose 50 MeSH
- Neurons drug effects MeSH
- Neurotoxicity Syndromes drug therapy physiopathology MeSH
- Obidoxime Chloride adverse effects therapeutic use MeSH
- Oximes adverse effects therapeutic use MeSH
- Rats, Wistar MeSH
- Psychomotor Performance drug effects MeSH
- Pyridinium Compounds adverse effects therapeutic use MeSH
- Cholinesterase Reactivators adverse effects therapeutic use MeSH
- Sarin antagonists & inhibitors toxicity MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Geographicals
- Czech Republic MeSH
- Names of Substances
- 1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)but-2-ene MeSH Browser
- Muscarinic Antagonists MeSH
- Antidotes MeSH
- asoxime chloride MeSH Browser
- Atropine MeSH
- Chemical Warfare Agents MeSH
- Cholinesterase Inhibitors MeSH
- Obidoxime Chloride MeSH
- Oximes MeSH
- Pyridinium Compounds MeSH
- Cholinesterase Reactivators MeSH
- Sarin MeSH
The neuroprotective effects of a newly developed oxime K203 and currently available oximes (obidoxime, HI-6) in combination with atropine in rats poisoned with sarin were studied. The sarin-induced neurotoxicity was monitored using a functional observatory battery at 2 hr after sarin challenge. The results indicate that the potency of a novel bispyridinium oxime K203 to counteract sarin-induced neurotoxicity is relatively low and roughly corresponds to the neuroprotective efficacy of obidoxime. Among tested oximes, the oxime HI-6 seems to be significanlty more efficacious to counteract acute neurotoxicity of sarin than commonly used obidoxime and a newly developed oxime K203. Thus, the oxime K203 does not provide any beneficial effect for the antidotal treatment of acute poisoning with sarin in comparison with the oxime HI-6 that should be considered to be the best oxime for antidotal treatment of acute sarin poisonings.
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