Význam mikroprostředí kostní dřeně v patogenezi mnohočetného myelomu
[Implication of bone marrow microenvironment in pathogenesis of multiple myeloma]
Language Czech Country Czech Republic Media print
Document type English Abstract, Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
22920162
PII: 38503
- MeSH
- Cytokines physiology MeSH
- Bone Marrow physiopathology MeSH
- Humans MeSH
- Intercellular Signaling Peptides and Proteins physiology MeSH
- Multiple Myeloma physiopathology MeSH
- Cell Adhesion Molecules physiology MeSH
- Plasma Cells physiology MeSH
- Check Tag
- Humans MeSH
- Publication type
- English Abstract MeSH
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Cytokines MeSH
- Intercellular Signaling Peptides and Proteins MeSH
- Cell Adhesion Molecules MeSH
Multiple myeloma is a hematooncological disease characterized by malignant proliferation of plasma cells. These cells accumulate in the bone marrow where they suppress physiological hematopoiesis; at the same time, these cells interact with a wide variety of cytokines, growth factors and adhesion molecules. It is obvious that the bone marrow microenvironment plays an important role in disease pathogenesis as well as treatment resistance.
