Effects of high tidal volume mechanical ventilation on production of cytokines, iNOS, and MIP-1β proteins in pigs
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Acute Lung Injury etiology metabolism MeSH
- Bronchoalveolar Lavage Fluid chemistry cytology MeSH
- Chemokine CCL4 metabolism MeSH
- Cytokines metabolism MeSH
- Tidal Volume MeSH
- Nitrates metabolism MeSH
- Nitrites metabolism MeSH
- Interleukin-8 metabolism MeSH
- Lung metabolism pathology physiopathology MeSH
- Pulmonary Alveoli metabolism pathology MeSH
- Lung Compliance physiology MeSH
- Swine MeSH
- Nitric Oxide Synthase Type II metabolism MeSH
- Tumor Necrosis Factor-alpha metabolism MeSH
- Respiration, Artificial adverse effects MeSH
- Positive-Pressure Respiration instrumentation MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Chemokine CCL4 MeSH
- Cytokines MeSH
- Nitrates MeSH
- Nitrites MeSH
- Interleukin-8 MeSH
- Nitric Oxide Synthase Type II MeSH
- Tumor Necrosis Factor-alpha MeSH
The aim of this study was to investigate longitudinal changes of the pulmonary inflammatory process as a result of mechanical stress due to mechanical ventilation. The concentrations of IL-8, TNF-α, MIP-1β, nitrites/nitrates, and inducible nitric oxide synthases (iNOS) were investigated indicate in bronchoalveolar lavage (BAL). Twenty-three piglets were divided into three groups. Group I: animals breathing spontaneously; group II: mechanical ventilation (tidal volume (TV) = 7 mL/kg, PEEP = 5 cmH(2)O); group III: mechanical ventilation (TV = 15 mL/kg, PEEP = 0 cmH(2)0). Concentrations of BAL nitrites/nitrates from groups II and III increased during the first hour of mechanical ventilation (P = .03 and .02, respectively). The highest expression of iNOS was observed during the first hour in groups II and III. IL-8 concentration increased significantly in groups II and III. Production of TNF-α increased significantly in group III during the second and third hour (P = .01). Concentration of MIP-1β was significantly increased in groups II and III after the first hour (P = .012 and P = .008, respectively).
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