Localization of c-MYB in differentiated cells during postnatal molar and alveolar bone development
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Ameloblasts metabolism MeSH
- Cell Differentiation genetics MeSH
- Connective Tissue Cells metabolism MeSH
- Genes, myc genetics MeSH
- In Situ Nick-End Labeling MeSH
- Molar cytology growth & development metabolism MeSH
- Mice MeSH
- Odontogenesis genetics MeSH
- Alveolar Process cytology growth & development metabolism MeSH
- Proto-Oncogene Proteins c-myb * analysis genetics metabolism MeSH
- Bone Development genetics physiology MeSH
- Gene Expression Regulation, Developmental genetics physiology MeSH
- Dental Cementum metabolism MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Proto-Oncogene Proteins c-myb * MeSH
The MYB family of transcription activators has been associated with a high proliferation rate and an undifferentiated state of cells in a number of tissues. Recently emerging data suggest that these molecules may also play a role in differentiation. In this study, the pattern of expression of c-MYB was followed during postnatal stages of mouse molar odontogenesis using immunohistochemistry on serial sections. Along with an abundance of the c-MYB protein in proliferating zones, we confirmed the presence of this protein in differentiated ameloblasts, odontoblasts, and osteoblasts. In addition, c-MYB was also found in cementoblasts and alveolar fibroblasts. These findings suggest integration of c-MYB into regulatory networks during hard-tissue differentiation and mineralization.
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