New insight into transcription of human endogenous retroviral elements
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
23201072
DOI
10.1016/j.nbt.2012.11.009
PII: S1871-6784(12)00866-7
Knihovny.cz E-resources
- MeSH
- Endogenous Retroviruses genetics MeSH
- Transcription, Genetic genetics MeSH
- Humans MeSH
- Organ Specificity MeSH
- Sequence Analysis, RNA MeSH
- DNA Transposable Elements genetics MeSH
- High-Throughput Nucleotide Sequencing MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- DNA Transposable Elements MeSH
It is generally assumed that human endogenous retroviral elements (HERVs) belong to the class of genomic repetitive nucleotide sequences often called 'junk DNA'. These elements were categorized to families, and members of some of these families (e.g. HERV-H, HERV-W and HERV-K) were shown to be transcribed. These transcriptions were associated with several severe diseases such as mental disorders, AIDS, autoimmune diseases and cancer. In this review we discuss several bioinformatics strategies for genome-wide scan of HERVs transcription using high-throughput RNA sequencing on several platforms. We show that many more HERVs than previously described are transcribed to various levels and we discuss possible implications of these transcriptions.
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