New insight into transcription of human endogenous retroviral elements
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
PubMed
23201072
DOI
10.1016/j.nbt.2012.11.009
PII: S1871-6784(12)00866-7
Knihovny.cz E-zdroje
- MeSH
- endogenní retroviry genetika MeSH
- genetická transkripce genetika MeSH
- lidé MeSH
- orgánová specificita MeSH
- sekvenční analýza RNA MeSH
- transpozibilní elementy DNA genetika MeSH
- vysoce účinné nukleotidové sekvenování MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- transpozibilní elementy DNA MeSH
It is generally assumed that human endogenous retroviral elements (HERVs) belong to the class of genomic repetitive nucleotide sequences often called 'junk DNA'. These elements were categorized to families, and members of some of these families (e.g. HERV-H, HERV-W and HERV-K) were shown to be transcribed. These transcriptions were associated with several severe diseases such as mental disorders, AIDS, autoimmune diseases and cancer. In this review we discuss several bioinformatics strategies for genome-wide scan of HERVs transcription using high-throughput RNA sequencing on several platforms. We show that many more HERVs than previously described are transcribed to various levels and we discuss possible implications of these transcriptions.
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