Markers of HPV infection and survival in patients with head and neck tumors
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
23564321
DOI
10.1002/ijc.28194
Knihovny.cz E-zdroje
- Klíčová slova
- HPV, antibodies, follow-up, head and neck cancer, oral rinses,
- MeSH
- DNA virů izolace a purifikace MeSH
- infekce papilomavirem * krev genetika imunologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- lidský papilomavirus 16 imunologie MeSH
- míra přežití MeSH
- nádorové biomarkery MeSH
- nádory hlavy a krku mortalita virologie MeSH
- onkogenní proteiny virové imunologie MeSH
- Papillomavirus E7 - proteiny imunologie MeSH
- prognóza MeSH
- protilátky virové krev MeSH
- represorové proteiny imunologie MeSH
- ústa virologie MeSH
- virové plášťové proteiny imunologie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- DNA virů MeSH
- E6 protein, Human papillomavirus type 16 MeSH Prohlížeč
- nádorové biomarkery MeSH
- oncogene protein E7, Human papillomavirus type 16 MeSH Prohlížeč
- onkogenní proteiny virové MeSH
- Papillomavirus E7 - proteiny MeSH
- protilátky virové MeSH
- represorové proteiny MeSH
- virové plášťové proteiny MeSH
The purpose of this study was to determine whether changes in human papillomavirus (HPV) DNA prevalence in oral rinses and/or HPV-specific antibody levels in the sera of patients with oral/oropharyngeal cancer have prognostic significance. One hundred and forty-two patients with oral/oropharyngeal tumors were enrolled. The presence of HPV DNA was assayed in tumor tissue and oral rinses and HPV-specific antibodies were assessed in the sera. Oral rinses were collected before treatment and one year after the treatment. Sera were drawn before treatment, one month, and one year after the end of the treatment. Altogether, 59.2% of tumors were HPV positive. The presence of HPV DNA in the tumors correlated with HPV DNA positivity in oral rinses and with HPV-specific antibodies in the sera. Out of 66 patients with HPV-positive oral rinses at enrolment, 84.8% became negative at one-year follow-up, while most patients remained seropositive for HPV-specific antigens. However, the mean titers of HPV16 E6 and/or E7 antibodies at follow-up were significantly lower. Of 16 patients with recurrences at follow-up (alive on second sampling), six were positive at enrolment for HPV16 E6 and/or E7 antibodies. In five of these, no decrease in antibody levels was observed. Titers of antibodies specific for HPV16 capsid antigens did not change during the follow-up. Our data suggest that the detection of antibodies specific for the HPV 16 E6 and E7 oncoproteins may serve not only as a marker of HPV etiology, but also as a marker of recurrence and a prognostic indicator in patients with HPV-positive tumors.
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