Markers of HPV infection and survival in patients with head and neck tumors
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
23564321
DOI
10.1002/ijc.28194
Knihovny.cz E-resources
- Keywords
- HPV, antibodies, follow-up, head and neck cancer, oral rinses,
- MeSH
- DNA, Viral isolation & purification MeSH
- Papillomavirus Infections * blood genetics immunology MeSH
- Middle Aged MeSH
- Humans MeSH
- Human papillomavirus 16 immunology MeSH
- Survival Rate MeSH
- Biomarkers, Tumor MeSH
- Head and Neck Neoplasms mortality virology MeSH
- Oncogene Proteins, Viral immunology MeSH
- Papillomavirus E7 Proteins immunology MeSH
- Prognosis MeSH
- Antibodies, Viral blood MeSH
- Repressor Proteins immunology MeSH
- Mouth virology MeSH
- Capsid Proteins immunology MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- DNA, Viral MeSH
- E6 protein, Human papillomavirus type 16 MeSH Browser
- Biomarkers, Tumor MeSH
- oncogene protein E7, Human papillomavirus type 16 MeSH Browser
- Oncogene Proteins, Viral MeSH
- Papillomavirus E7 Proteins MeSH
- Antibodies, Viral MeSH
- Repressor Proteins MeSH
- Capsid Proteins MeSH
The purpose of this study was to determine whether changes in human papillomavirus (HPV) DNA prevalence in oral rinses and/or HPV-specific antibody levels in the sera of patients with oral/oropharyngeal cancer have prognostic significance. One hundred and forty-two patients with oral/oropharyngeal tumors were enrolled. The presence of HPV DNA was assayed in tumor tissue and oral rinses and HPV-specific antibodies were assessed in the sera. Oral rinses were collected before treatment and one year after the treatment. Sera were drawn before treatment, one month, and one year after the end of the treatment. Altogether, 59.2% of tumors were HPV positive. The presence of HPV DNA in the tumors correlated with HPV DNA positivity in oral rinses and with HPV-specific antibodies in the sera. Out of 66 patients with HPV-positive oral rinses at enrolment, 84.8% became negative at one-year follow-up, while most patients remained seropositive for HPV-specific antigens. However, the mean titers of HPV16 E6 and/or E7 antibodies at follow-up were significantly lower. Of 16 patients with recurrences at follow-up (alive on second sampling), six were positive at enrolment for HPV16 E6 and/or E7 antibodies. In five of these, no decrease in antibody levels was observed. Titers of antibodies specific for HPV16 capsid antigens did not change during the follow-up. Our data suggest that the detection of antibodies specific for the HPV 16 E6 and E7 oncoproteins may serve not only as a marker of HPV etiology, but also as a marker of recurrence and a prognostic indicator in patients with HPV-positive tumors.
References provided by Crossref.org
PD1+CD8+ Cells Are an Independent Prognostic Marker in Patients with Head and Neck Cancer
ARG1 mRNA Level Is a Promising Prognostic Marker in Head and Neck Squamous Cell Carcinomas
