Detection of cancer stem cell markers in sarcomas
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
23581011
Knihovny.cz E-resources
- MeSH
- ATP-Binding Cassette Transporters analysis MeSH
- Aldehyde Dehydrogenase analysis MeSH
- AC133 Antigen MeSH
- Antigens, CD analysis MeSH
- Glycoproteins analysis MeSH
- Humans MeSH
- Biomarkers, Tumor analysis MeSH
- Neoplastic Stem Cells metabolism MeSH
- Nestin MeSH
- Peptides analysis MeSH
- Intermediate Filament Proteins analysis MeSH
- Nerve Tissue Proteins analysis MeSH
- Sarcoma diagnosis metabolism MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- ATP-Binding Cassette Transporters MeSH
- Aldehyde Dehydrogenase MeSH
- AC133 Antigen MeSH
- Antigens, CD MeSH
- Glycoproteins MeSH
- Biomarkers, Tumor MeSH
- NES protein, human MeSH Browser
- Nestin MeSH
- Peptides MeSH
- PROM1 protein, human MeSH Browser
- Intermediate Filament Proteins MeSH
- Nerve Tissue Proteins MeSH
The identification of cancer stem cell markers represents one of the very relevant research topics because cancer stem cells play important roles in tumour initiation and progression, as well as during metastasis formation and in relapse of the disease. This article summarises recent knowledge on well-known and putative cancer stem cell markers in various types of bone and soft-tissue sarcomas. Special attention is paid to the detection of CD133, ABC transporters, nestin and aldehyde dehydrogenase that have been intensively studied both in tumour tissues and in sarcoma cell lines during the past few years. Finally, an overview is given of the possible CSC phenotypes provided by functional assays of tumourigenicity.
Nestin as a marker of cancer stem cells
Atypical nuclear localization of CD133 plasma membrane glycoprotein in rhabdomyosarcoma cell lines
