Common biomarkers of oxidative stress do not reflect cardiovascular dys/function in rats
Jazyk angličtina Země Česko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
23733147
DOI
10.5507/bp.2013.033
Knihovny.cz E-zdroje
- MeSH
- biologické markery krev MeSH
- kardiovaskulární nemoci * krev patofyziologie MeSH
- kardiovaskulární systém * metabolismus patofyziologie MeSH
- krysa rodu Rattus MeSH
- oxidační stres fyziologie MeSH
- potkani Wistar MeSH
- tepový objem MeSH
- troponin T krev MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- biologické markery MeSH
- troponin T MeSH
BACKGROUND: Predicting cardiovascular events remains challenging despite the range of known biomarkers. AIM: To establish relationships between various biochemical and functional parameters of the cardiovascular system. METHOD: The relationship between cardiovascular dys/function and various biomarkers was examined in 145 experimental rats half of which received isoprenaline 100 mg/kg s.c. to induce cardiac impairment. RESULTS: Serum concentration of cardiac troponin T (cTnT), a known marker of cardiac derangement, correlated strongly with degree of myocardial injury (e.g. calcium overload, stroke volume) but correlations between cTnT and oxidative stress parameters were weak (for glutathione and vitamin C) or not found (for serum vitamin E and plasma thiobarbituric acid reactive substances levels). Relationships between cTnT and other parameters were exponential with the exception of myocardial calcium, where a power function was found. CONCLUSIONS: Commonly used biomarkers of oxidative stress cannot reliably predict cardiovascular dys/function in experimental rats.
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