Trilobolide and related sesquiterpene lactones from Laser trilobum possessing immunobiological properties
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
23747321
DOI
10.1016/j.fitote.2013.05.025
PII: S0367-326X(13)00145-7
Knihovny.cz E-resources
- Keywords
- Cytokine, Laser trilobum, Nitric oxide, Sesquiterpene, Thapsigargin, Trilobolide,
- MeSH
- Adjuvants, Immunologic isolation & purification pharmacology MeSH
- Apiaceae chemistry MeSH
- Butyrates isolation & purification pharmacology MeSH
- Cytokines metabolism MeSH
- Furans isolation & purification pharmacology MeSH
- Plant Roots chemistry MeSH
- Rats MeSH
- Lactones isolation & purification pharmacology MeSH
- Molecular Structure MeSH
- Nitric Oxide biosynthesis MeSH
- Rats, Wistar MeSH
- Plant Extracts chemistry pharmacology MeSH
- Sesquiterpenes isolation & purification pharmacology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Adjuvants, Immunologic MeSH
- Butyrates MeSH
- Cytokines MeSH
- Furans MeSH
- Lactones MeSH
- Nitric Oxide MeSH
- Plant Extracts MeSH
- Sesquiterpenes MeSH
- trilobolide MeSH Browser
Three new and five known sesquiterpene lactones were isolated from the roots of Laser trilobum (L.) Borkh. Chemical identity of the known compounds and structural analysis of the new ones were determined by HR MS and NMR spectroscopy. The two new sesquiterpene lactones: 2-acetoxytrilobolide and 2-hydroxy-10-deacetyltrilobolide belong to the guaianolide type, and the third one, eudeslaserolide, to the biogenetically related eudesmanolide type. Both types, together with their biogenetic precursor of germacranolide type (laserolide) are present in L. trilobum, as well as in the related Laserpitium species. Purposefully selected set of these native sesquiterpene lactones was tested for specific immunobiological properties. The obtained results demonstrate that trilobolide and its acetoxy analog are strong activators of cytokine secretion. On the contrary, the other L. trilobum and Laserpitium siler constituents are only very mild activators, or even inhibitors of the cytokine and nitric oxide production.
References provided by Crossref.org
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