Molecular phylogeography of tick-borne encephalitis virus in central Europe
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Phylogeography * MeSH
- Genotype MeSH
- Ticks virology MeSH
- Molecular Epidemiology MeSH
- Molecular Sequence Data MeSH
- Viral Envelope Proteins genetics MeSH
- Mammals virology MeSH
- Sequence Analysis, DNA MeSH
- Cluster Analysis MeSH
- Encephalitis Viruses, Tick-Borne classification genetics isolation & purification MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Europe MeSH
- Names of Substances
- glycoprotein E, Flavivirus MeSH Browser
- Viral Envelope Proteins MeSH
In order to obtain a better understanding of tick-borne encephalitis virus (TBEV) strain movements in central Europe the E gene sequences of 102 TBEV strains collected from 1953 to 2011 at 38 sites in the Czech Republic, Slovakia, Austria and Germany were determined. Bayesian analysis suggests a 350-year history of evolution and spread in central Europe of two main lineages, A and B. In contrast to the east to west spread at the Eurasian continent level, local central European spreading patterns suggest historic west to east spread followed by more recent east to west spread. The phylogenetic and network analyses indicate TBEV ingressions from the Czech Republic and Slovakia into Germany via landscape features (Danube river system), biogenic factors (birds, red deer) and anthropogenic factors. The identification of endemic foci showing local genetic diversity is of paramount importance to the field as these will be a prerequisite for in-depth analysis of focal TBEV maintenance and long-distance TBEV spread.
Bundeswehr Institute of Microbiology 80937 Munich Germany
Department of Virology University Medical Center 37075 Göttingen Germany
Department of Virology Veterinary Research Institute Hudcova 70 CZ 62100 Brno Czech Republic
Institute of Animal Hygiene and Veterinary Public Health University of Leipzig Leipzig Germany
Institute of Parasitology Slovak Academy of Science Kosice Slovakia
Institute of Virology Charité University Hospital Berlin Germany
Institute of Virology Slovak Academy of Science Dubravska cesta 9 84505 Bratislava Slovakia
References provided by Crossref.org
