MicroRNAs targeting EGFR signalling pathway in colorectal cancer
Language English Country Germany Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
- MeSH
- ErbB Receptors genetics metabolism MeSH
- Colorectal Neoplasms genetics metabolism MeSH
- Humans MeSH
- MicroRNAs genetics MeSH
- Biomarkers, Tumor genetics MeSH
- Protein Kinases genetics metabolism MeSH
- Gene Expression Regulation, Neoplastic MeSH
- RNA Interference MeSH
- Signal Transduction MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- EGFR protein, human MeSH Browser
- ErbB Receptors MeSH
- MicroRNAs MeSH
- Biomarkers, Tumor MeSH
- Protein Kinases MeSH
MicroRNAs (miRNAs) are short, 18-25-nucleotide long, non-coding single-stranded RNAs, which are capable to regulate gene expression on post-transcriptional level through binding to their target protein-encoding mRNAs. miRNAs regulate individual components of multiple oncogenic pathways. One of them is epidermal growth factor receptor (EGFR) signalling pathway that regulates cell proliferation, differentiation, migration, angiogenesis and apoptosis. All these processes are deregulated in colorectal cancer (CRC). Moreover, EGFR has been validated as the therapeutic target in CRC, and monoclonal antibodies cetuximab and panitumumab are used in the therapy of patients with metastatic CRC. Because of the extensive involvement of miRNAs in the regulation of EGFR signalling, it seems they could also serve as promising predictive biomarkers to anti-EGFR therapy. In this review, we summarize current knowledge about miRNAs targeting EGFR signalling pathway, their functioning in CRC pathogenesis and potential usage as biomarkers.
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