Direct C-H sulfenylation of purines and deazapurines
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
23824343
DOI
10.1039/c3ob40881g
Knihovny.cz E-resources
- MeSH
- Crystallography, X-Ray MeSH
- Copper chemistry MeSH
- Purines chemistry MeSH
- Sulfur chemistry MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- 7-deazapurine MeSH Browser
- Copper MeSH
- purine MeSH Browser
- Purines MeSH
- Sulfur MeSH
A general method for Cu-catalyzed C-H sulfenylation of purines, 7-deaza- and 9-deazapurines with aryl- or alkyldisulfides has been developed. In purines, the reaction occurs at position 8, in 7-deazapurines at position 7 and in 9-deazapurines at position 9, leading to new interesting arylsulfanyl derivatives of purine or deazapurine bases. The resulting 8-arylsulfanylpurines undergo Liebesking-Srogl coupling with arylstannanes or boronic acids, whereas the (arylsulfanyl)deazapurines are not reactive under these conditions.
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