Serum and cerebrospinal fluid light neurofilaments and antibodies against them in clinically isolated syndrome and multiple sclerosis
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
23870535
DOI
10.1016/j.jneuroim.2013.06.010
PII: S0165-5728(13)00169-0
Knihovny.cz E-zdroje
- Klíčová slova
- Antibody, Cerebrospinal fluid, Clinically isolated syndrome, Light neurofilament subunit, Multiple sclerosis, Serum,
- MeSH
- autoprotilátky biosyntéza krev mozkomíšní mok MeSH
- axony patologie MeSH
- biologické markery krev mozkomíšní mok MeSH
- demyelinizační nemoci krev mozkomíšní mok imunologie MeSH
- dospělí MeSH
- lidé MeSH
- mladý dospělý MeSH
- neurofilamentové proteiny krev mozkomíšní mok imunologie MeSH
- prodromální symptomy MeSH
- roztroušená skleróza krev mozkomíšní mok imunologie MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- autoprotilátky MeSH
- biologické markery MeSH
- neurofilament protein L MeSH Prohlížeč
- neurofilamentové proteiny MeSH
A release of light neurofilament subunits (NFL) into cerebrospinal fluid (CSF) and serum in multiple sclerosis (MS) may induce an immune response. We examined CSF and serum NFL levels and IgG antibodies against NFL in 19 patients with a clinically isolated syndrome (CIS) early converted into MS, 20 CIS-non-converters, 23 MS patients and 32 controls. CSF NFL levels were significantly higher in all patient groups. The highest CSF or intrathecally (IT) synthesized anti-NFL antibodies and CSF/serum ratios of anti-NFL antibodies were observed in CIS-converters. CSF NFL and CSF or IT anti-NFL antibodies could be surrogate biomarkers of axonal injury in early MS.
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