A single-parameter logistic equation for fitting concentration-response curves from standard acute ecotoxicity assays
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
23881720
DOI
10.1002/etc.2328
Knihovny.cz E-resources
- Keywords
- Acute ecotoxicity assays, Concentration-response slope, EC50 calculation, Logistic model,
- MeSH
- Aliivibrio fischeri drug effects MeSH
- Chlorophyta drug effects MeSH
- Daphnia drug effects MeSH
- Potassium Dichromate toxicity MeSH
- Environmental Pollutants toxicity MeSH
- Logistic Models * MeSH
- Reference Standards MeSH
- Toxicity Tests, Acute * standards MeSH
- Poecilia MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Potassium Dichromate MeSH
- Environmental Pollutants MeSH
A set of 69 concentration-response curves from 5 acute ecotoxicity assays was fitted with a 2-parameter logistic equation. High correlation between values of regression parameters suggested similar slopes of the curves. This enabled derivation of the empirical single-parameter logistic equation with the sole median effective concentration (EC50) parameter. Such an equation might be useful in the evaluation of lower-quality (preliminary) experimental data and for the reduction of the number of test organisms and of testing costs.
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