Fine tuning of the pH-dependent drug release rate from polyHPMA-ellipticinium conjugates

. 2013 Sep 15 ; 21 (18) : 5669-72. [epub] 20130727

Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/pmid23941688
Odkazy

PubMed 23941688
DOI 10.1016/j.bmc.2013.07.038
PII: S0968-0896(13)00659-7
Knihovny.cz E-zdroje

Polymer conjugates of anticancer drugs have shown high potential for assisting in cancer treatments. The pH-labile spacers allow site-specific triggered release of the drugs. We synthesized and characterized model drug conjugates with hydrazide bond-containing poly[N-(2-hydroxypropyl)methacrylamide] differing in the chemical surrounding of the hydrazone bond-containing spacer to find structure-drug release rate relationships. The conjugate selected for further studies shows negligible drug release in a pH 7.4 buffer but released 50% of the ellipticinium drug within 24h in a pH 5.0 phosphate saline buffer. The ellipticinium drug retained the antiproliferative activity of the ellipticine.

Citace poskytuje Crossref.org

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