Embryonic stem cells are mostly derived from mature oocytes that were either fertilized or activated parthenogenetically and then reached the blastocyst stage. From the cell cycle perspective, fertilization or activation induces the exit from meiosis, decondensation of oocyte chromosomes, and the entry into mitosis. Decondensation of oocyte chromatin with subsequent formation of nuclei can be, however, induced at any postgerminal vesicle breakdown meiotic maturation stage. In this article, we discuss the possibility of cleavage of transformed maturing oocytes and whether they can reach the blastocyst stage, from which pluripotent stem cell lines could be derived.

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Bonnet-Garnier A. Feuerstein P. Chebrout M. Fleurot R. Habib-Ullah J. Debey P. Beaujean N. Genome organization and epigenetic marks in mouse germinal vesicle oocytes. Int. J. Dev. Biol. 2013;56:877–887. PubMed

Chen Z. Liu Z. Huang J. Amano T. Li C. Cao S. Wu C. Liu B. Zhou L. Carter M.G. Keefe D.L. Yang X. Liu L. Birth of parthenote mice directly from parthenogenetic embryonic stem cells. Stem Cells. 2009;27:2136–2145. PubMed

Clarke H.J. Masui Y. The induction of reversible and irreversible chromosome decondensation by protein synthesis inhibition during meiotic maturation of mouse oocytes. Dev. Biol. 1983;97:291–301. PubMed

Clarke H.J. Masui Y. Inhibition by dibutyryl cyclic AMP of the transition to metaphase of mouse oocyte nuclei and its reversal by cell fusion to metaphase oocytes. Dev. Biol. 1985;108:32–37. PubMed

Clarke H.J. Rossant J. Masui Y. Suppression of chromosome condensation during meiotic maturation induces parthenogenetic development of mouse oocytes. Development. 1988;104:97–103. PubMed

Fulka J., Jr. First N.L. Moor R.M. Nuclear and cytoplasmic determinants involved in the regulation of mammalian oocyte maturation. Mol. Hum. Reprod. 1998;4:41–49. PubMed

Fulka J., Jr. First N.L. Fulka J. Moor R.M. Checkpoint control of the G2/M phase transition during the first mitotic cycle in mammalian eggs. Hum. Reprod. 1999;14:1582–1587. PubMed

Fulka H. Hirose M. Inoue K. Ogonuki N. Wakisaka N. Matoba S. Ogura A. Mosko T. Kott T. Fulka J., Jr. Production of mouse embryonic stem cell lines from maturing oocytes by direct conversion of meiosis into mitosis. Stem Cells. 2011;29:517–527. PubMed

Hashimoto N. Kishimoto T. Regulation of meiotic metaphase by a cytoplasmic maturation-promoting factor during mouse oocyte maturation. Dev. Biol. 1988;126:242–252. PubMed

Jones K.T. Turning it on and off: M-phase promoting factor during maturation and fertilization. Mol. Hum. Reprod. 2004;10:1–5. PubMed

Langerova A. Chromatin acetylation in human oocytes. Ginekol. Pol. 2013;84:263–267. PubMed

Li R. Albertini D.F. The road to maturation: Somatic cell interaction and self-organization of the mammalian oocyte. Nat. Rev. Mol. Cell Bio. 2013;14:141–152. PubMed

McLay D.W. Clarke H.J. Remodelling the paternal chromatin at fertilization in mammals. Reproduction. 2003;125:625–633. PubMed PMC

Morris S.A. Daley G.Q. A blueprint for engineering cell fate: Current technologies to reprogram cell identity. Cell Res. 2013;23:33–48. PubMed PMC

Nagaoka S.I. Hassold T.J. Hunt P.A. Human aneuploidy: Mechanisms and new insights into an age-old problem. Nat. Rev. Genet. 2012;13:493–504. PubMed PMC

Nagy A. Paldi A. Dezso L. Varga L. Magyar A. Prenatal fate of parthenogenetic cells in mouse aggregation chimaeras. Development. 1987;101:67–71. PubMed

Paldi A. Nagy A. Markkula M. Barna I. Dezso L. Postnatal development of parthenogenetic in equilibrium with fertilized mouse aggregation chimeras. Development. 1989;105:115–118. PubMed

Szollosi M.A. Debey P. Szollosi D. Rime H. Vautier D. Chromatin behaviour under influence of puromycin and 6-DMAP at different stages of mouse oocyte maturation. Chromosoma. 1991;100:339–354. PubMed

van den Berg I.M. Eleveld C. van der Hoeven M. Birnie E. Steegers E.A.P. Galjaard R.J. Laven J.S.E. van Doornick J.H. Defective deacetylation of histone 4 K12 is associated with advanced maternal age and chromosome misalignment. Hum. Reprod. 2011;26:1181–1190. PubMed

Yamanaka S. Induced pluripotent stem cells: past, present, and future. Cell Stem Cell. 2012;10:678–684. PubMed